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Gut peptide GLP-1 and its analogue, exendin-4, decrease alcohol intake and reward
Thats a tough sell that some weight-loss drug patients are struggling with
In 1959, a notable advancement was made in the study of specific phenotypes with the identification of Trisomy 21 (Down syndrome), the most prevalent chromosomal disorder, which was initially described by John Langdon Down in 1866
It targets multiple factors at once, unlike other medications like phentermine, which mainly suppresses appetite, or orlistat, which blocks fat absorption
In a separate follow up Phase 2a study over 49 days, the mechanism of improved glycaemia was shown to be a combination of enhanced insulin secretion and delayed gastric emptying (84)
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